Thymosin Alpha 1 (TA1) is a synthetic peptide fragment of thymosin fraction 5, comprising 28 amino acids. Originally isolated from the thymus gland, TA1 has gained attention in immunological research for its potential to modulate immune function, particularly in immunodeficient conditions. This product is intended for in-vitro research use only.
Key Features
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Purity: ≥99% by HPLC
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Form: Lyophilized powder
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Molecular Formula: C129H215N33O55
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Molecular Weight: 3108.33 g/mol
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Origin: USA-manufactured under ISO-certified conditions
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Packaging: Sealed vial, nitrogen-purged, tamper-proof cap
Research Applications
Thymosin Alpha-1 is widely studied for its effects on:
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Immune response modulation
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T-cell activation
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Chronic viral infections (e.g., hepatitis B/C – preclinical use only)
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Cancer immunotherapy adjunct research
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Vaccine enhancement mechanisms
Storage & Reconstitution
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Reconstitution: Reconstitute with bacteriostatic water (0.6–1.0 mL recommended per 1mg vial)
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Storage (lyophilized): Store at -20°C for long-term use
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After reconstitution: Keep refrigerated at 2–8°C and use within 30 days
Thymosin Alpha 1 Injection
Thymosin Alpha-1 Injection refers to a liquid or reconstituted peptide solution used strictly in a research context to study the immunomodulatory effects of Thymosin Alpha-1 (TA1). TA1 is a 28-amino acid peptide originally derived from prothymosin alpha, a natural thymic hormone known for its role in immune system regulation.
Although some international medical settings have explored its therapeutic value, in the United States and many other regions, TA1 injections are not FDA-approved for personal use and are sold exclusively for laboratory or investigational purposes.
Mechanism of Action (Research Context)
Thymosin Alpha-1 works primarily by:
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Activating T lymphocytes, especially CD4+ helper and CD8+ cytotoxic cells
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Enhancing the Th1 immune response, which supports antiviral and antitumor activity
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Modulating dendritic cell function for improved antigen presentation
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Suppressing chronic inflammation markers in research models
Research Applications
Thymosin Alpha-1 injection is currently studied for:
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Chronic viral infection models (e.g., hepatitis B, C, and HIV)
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Cancer immunotherapy support (e.g., melanoma, lung cancer)
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Autoimmune disease modulation
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Immunodeficiency investigations
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Vaccine adjuvant studies
Dosage and Administration (Research Use Only)
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Typical concentration: 1mg per mL after reconstitution
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Delivery method: Subcutaneous or intramuscular injection in laboratory models
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Frequency in studies: Often administered 1–2 times weekly for 4–8 weeks, depending on research goals
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Solvent: Bacteriostatic water is typically used to reconstitute the lyophilized TA1 powder
Storage Guidelines
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Unreconstituted (lyophilized): Store at -20°C
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After reconstitution: Store between 2°C and 8°C; use within 20–30 days
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Protect from light and temperature fluctuation
What is Thymosin Alpha 1
Thymosin Alpha-1 (TA1) is a synthetic 28-amino acid peptide originally derived from a naturally occurring protein called prothymosin alpha, which is produced by the thymus gland. Its primary function is to support and regulate the immune system.
What Does Thymosin Alpha 1 Do?
Thymosin Alpha-1 is classified as an immunomodulator, meaning it helps balance and enhance immune responses. It does not stimulate the immune system blindly but rather improves its targeted effectiveness, especially in response to infections, cancer cells, or weakened immunity.
Key mechanisms include:
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Boosting T-cell activity, especially CD4+ and CD8+ lymphocytes
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Promoting dendritic cell maturation (key for antigen presentation)
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Enhancing production of interferons and cytokines (natural antiviral signals)
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Reducing chronic inflammation markers in certain conditions
Frequently Asked Questions (FAQs) – Thymosin Alpha-1
1. What is Thymosin Alpha-1?
Thymosin Alpha-1 (TA1) is a synthetic 28-amino acid peptide originally derived from a naturally occurring protein in the thymus gland. It is widely researched for its ability to modulate and enhance immune system responses.
2. What is Thymosin Alpha-1 used for in research?
TA1 is commonly studied in preclinical and laboratory settings for its potential roles in:
- Enhancing T-cell function
- Supporting immune response against viral infections
- Adjunct cancer immunotherapy research
- Investigating chronic inflammatory conditions
- Serving as a vaccine adjuvant
3. Is Thymosin Alpha-1 approved for human use?
In the United States, UK, and Australia, Thymosin Alpha-1 is not approved for human or veterinary use outside of clinical trials. It is sold for research purposes only. However, it has been approved under the trade name Zadaxin (Thymalfasin) in some countries like China and Italy for limited medical use.
4. How is Thymosin Alpha-1 administered in research?
It is typically reconstituted with bacteriostatic water and administered via:
- Subcutaneous injection (most common in lab animals)
- Intramuscular injection (less frequent)
Dosage and frequency depend on the research protocol and study model.
5. What are the potential side effects observed in studies?
In published research and international clinical trials, side effects have been reported rarely, but may include:
- Mild injection site reactions
- Fatigue or low-grade fever
- Headache or body aches
Note: These observations are from clinical research settings only, not general use.
6. How should Thymosin Alpha-1 be stored?
- Lyophilized form (powder): Store at -20°C in a dry, dark place
- Reconstituted form: Store between 2°C–8°C and use within 20–30 days
Avoid repeated freeze-thaw cycles and keep out of direct sunlight.
7. Is Thymosin Alpha-1 the same as Thymosin Beta-4?
No. Thymosin Alpha-1 and Thymosin Beta-4 (TB-500) are different peptides with different structures and biological functions. TA1 is primarily studied for immune modulation, while TB-500 is studied for tissue repair and regeneration.
8. Is it legal to purchase Thymosin Alpha-1 online?
Yes, but only for research purposes. It is legal to purchase Thymosin Alpha-1 from peptide vendors or suppliers if you are:
- A qualified researcher
- Representing a licensed lab or institution
- Using it solely for in-vitro or preclinical studies
Unauthorized sale or use for self-administration may violate national regulations.
9. What is the typical concentration or dosage used in studies?
Research dosages often range from 1mg to 3mg per injection, administered once or twice per week, depending on the experimental model. These values are not intended for clinical application and should not be interpreted as medical advice.
10. Can Thymosin Alpha-1 be stacked with other peptides in research?
Yes. In some studies, Thymosin Alpha-1 has been combined with:
- Interferon therapies
- Cancer treatments (like checkpoint inhibitors)
- Other peptides such as GHK-Cu or TB-500, depending on the study objective
All combinations must be evaluated for interaction risk and research validity.
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