Melanostatin DM 200mg
Melanostatin DM is an inhibitor of a-melanocyte stimulating hormone (a-MSH), which is the primary hormone that controls production of melanin pigment. By inhibiting the effects of a-MSH, Melanostatin DM is able to lighten skin tone and even out skin coloration in laboratory experiments. It may be useful for the treatment of photodamage (skin discoloration due to sun exposure) as well as other conditions in which melanin production needs to be reduced.
Research Application
Melanostatin DM is being actively invested in animal and in vitro models for its ability to interfere with melanin production. The molecule is thought to interfere with tyrosinase activity by inhibiting the actions of a-MSH. It may be useful in the treatment of disease that cause skin discoloration, such as Addison’s disease and diabetes.
What Is Melanostatin DM?
Melanostatin DM (His-D-Arg-Ala-Trp-D-Phe-Lys) is a synthetic version of melanostatin, a naturally occurring molecule derived from oxytocin. Melanostatin (also called melanocyte-inhibiting factor) is made up of just three amino acids (Pro-Leu-Gly) and is capable of blocking the effects of the opioid receptor, activating dopamine receptors, and inhibiting the release of neuropeptides like a-MSH. Melanostatin DM, due to its extended amino acid sequence and structure, has been shown to affect only a-MSH signaling in animal studies.
What Does Melanostatin DM Do?
Melanostatin DM is a radiance promoter and whitening agent. That means that it can interfere with the synthesis of melanin to lighten skin tone and reduce pigmentation. In animal models, Melanostatin DM has been found to antagonize a-MSH, a common signaling molecular that tells melanocytes (pigment cells) to product melanin. a-MSH can increase in humans during pregnancy, as a result of sun exposure, and in certain disease states.
By interfering with the effects of a-MSH, Melanostatin DM can prevent the tyrosinase enzyme from being activated. Tyrosinase is directly responsible for the production of melanin. By preventing melanin production, Melanostatin DM can prevent and reverse skin darkening.
Melanostatin DM Research and the Reduction in Skin Discoloration
In animal studies and during testing in human skin cells grown in the laboratory, Melanostatin DM has been shown to significantly reduce the production of melanin in melanocytes. In most cases, melanostatin can inhibit about 25% of melanin production. Unfortunately, most of the research on this molecule is propriety and thus cannot be accessed.
FAQs for Melanostatin DM 200mg (Topical)
1. What is Melanostatin DM 200mg (Topical)?
Melanostatin DM is a synthetic peptide used in topical formulations to help regulate melanin production and reduce hyperpigmentation. It is commonly applied in skincare products for skin brightening.
2. How does Melanostatin DM work?
Melanostatin DM functions as a melanotropin antagonist, meaning it blocks the action of alpha-MSH (melanocyte-stimulating hormone), which is responsible for melanin synthesis. This helps control pigmentation and even skin tone.
3. What are the benefits of using Melanostatin DM topically?
Benefits include reduced appearance of dark spots, improved skin tone uniformity, prevention of UV-induced pigmentation, and enhanced overall skin brightness.
4. Is Melanostatin DM safe for all skin types?
Yes, Melanostatin DM is generally considered safe for all skin types when used as directed in topical cosmetic formulations. However, a patch test is always recommended before full application.
5. How should Melanostatin DM 200mg be used?
It should be used as part of a topical serum, cream, or lotion, applied to clean skin once or twice daily, depending on product instructions. Avoid contact with eyes and broken skin.
6. Can Melanostatin DM be used with other skincare ingredients?
Yes, it can typically be combined with other peptides, antioxidants, and hydrating agents. However, consult the product manufacturer or a skincare professional for compatibility.
7. Is Melanostatin DM approved for medical use?
No, Melanostatin DM is used for cosmetic and research purposes only. It is not approved for therapeutic or drug use.
8. How should Melanostatin DM 200mg be stored?
Store in a cool, dry place, ideally between 2°C to 8°C, and keep away from direct sunlight and moisture to maintain its stability.
Nicole Hayes –
Calms my skin and evens pigmentation.
Patrick Simmons –
Amazing for my uneven skin tone. Love it!
Lily Sanders –
It helped reduce the appearance of dark areas.
George Rivera –
Perfect for my sensitive skin.
Jennifer Collins –
I saw results in a week. Skin looks more even.