IGF1 LR3

COA IGF-1 LR3 (Receptor Grade) 100mcg x 10 Vials Certificate

 

IGF1 LR3 (Insulin-Like Growth Factor-1 Long R3) is a synthetic peptide designed to enhance muscle growth, improve recovery, and support cellular repair. It is a modified version of the naturally occurring IGF-1, engineered with a longer half-life and higher potency, making it more effective in stimulating muscle cell proliferation and preventing muscle degradation. Commonly used in research settings, IGF-1 LR3 is valued for its ability to promote lean muscle mass, increase endurance, and accelerate recovery from intense physical activity or injury. For research purposes only. Not intended for human consumption.

IGF 1 LR3 Dosage 

The recommended IGF 1 LR3 dosage varies depending on the research purpose, but common research protocols typically range from 20mcg to 100mcg per day. Due to its extended half-life of approximately 20–30 hours, IGF 1 LR3 is often administered once daily, either subcutaneously or intramuscularly. Some studies divide the dosage into pre- and post-workout injections to enhance muscle growth and recovery. Accurate dosing is critical, as excessive amounts may lead to adverse effects such as hypoglycemia or tissue desensitization. Always consult research guidelines or a qualified professional before use. For laboratory research only.

Best IGF 1 LR3 Suppliers 

1. Peptide Sciences

One of the most respected US-based peptide companies offering IGF‑1 LR3 at high purity (≈ 98–99%). They provide a full Certificate of Analysis (COA), including HPLC and mass spectrometry verification. Their product is clearly labeled for research use only and backed by in-depth technical documentation — ideal for lab-based studies.

2. SwissChems

A USA-sourced brand that sells 1 mg vials of IGF‑1 LR3 with independent lab testing. They emphasize rigorous quality control and customer assurance: if their product doesn’t pass an external HPLC test, the purchase is refunded — making them a trusted choice for consistency .

3. PureRawz

Marketed specifically for research use, PureRawz includes third-party COAs with each IGF‑1 LR3 purchase. They’re well-reviewed in scientific circles and noted repeatedly as a “most reliable resource”.

4. Biotech Peptides

U.S.-based, offering receptor-grade IGF‑1 LR3 in 100 µg and 1 mg formats with high purity. They’re transparent about their synthesis and labelling as research-grade materials.

5. R&D Systems

A globally recognized biotech supplier providing GMP-grade, carrier-free IGF‑1 LR3 protein. Their product is manufactured in ISO-certified facilities and is well-suited for advanced cell therapy, ex‑vivo, or preclinical research.

How to Choose a Supplier

Summary

If you’re sourcing IGF‑1 LR3 for research purposes only, reputable suppliers include:

• Peptide Sciences (US-made, high purity, full COA)

• SwissChems (lab-tested with money-back guarantee)

• PureRawz (includes verified 3rd-party analysis)

• Biotech Peptides (receptor-grade, US-synthesized)

• R&D Systems (GMP-grade for advanced studies)

Each offers clear labeling for research use, provides thorough purity data, and is well-regarded for quality and reliability. Always verify the supplier’s documentation and compliance before ordering.

HPLC IGF-1 LR3 (Receptor Grade) 100mcg x 10 Vials Certificate

MS IGF-1 LR3 (Receptor Grade) 100mcg x 10 Vials Certificate

IGF1 LR3 Research

Cell Divison

Like IGF 1, IGF1 LR3 is a potent stimulus for cell division and proliferation. Its primary effects are on connective tissues like muscle and bone, but it also promotes cell division in liver, kidney, nerve, skin, lung, and blood tissues. IGF 1 is best thought of as a maturation hormone because it not only promotes cell proliferation, but differentiation as well. IGF 1 causes cells to mature, in other words, so that they can carry out their specialized functions.
Unlike IGF 1, IGF1 LR3 remains in the bloodstream for long periods of time. This property makes IGF1 LR3 a much more potent molecule. A dose of IGF1 LR3 provides approximately three times as much cell activation as a similar dose of IGF 1. Note that IGF1 LR3 and all IGF 1 derivatives do not promote cell enlargement (hypertrophy), but rather promote cell division and proliferation (hyperplasia). In the case of muscle, for instance, IGF1 LR3 does not cause muscle cells to get larger, but it does increase total numbers of muscle cells.

Fat Metabolism and Diabetes

IGF1 LR3 boosts fat metabolism in an indirect manner by binding to both the IGF 1R receptor and the insulin receptor. These actions increase glucose uptake from the blood by muscle, nerve, and liver cells. This results in an overall decrease in blood sugar levels, which then triggers adipose tissue as well as the liver to begin breaking down glycogen and triglycerides. Overall, this produces a net decrease in adipose tissue and a net energy consumption (i.e. net catabolism).

Given its role in reducing blood sugar levels, it should come as no surprise that IGF1 LR3 reduces insulin levels as well as the need for exogenous insulin in diabetes. In most cases, this translates into a 10% decrease in insulin requirements to maintain the same blood sugar levels. This fact may help scientists understand how to decrease insulin doses in individuals who have decreased insulin sensitivity and may even offer insight into preventing type 2 diabetes in the first place.

Impairs Myostatin

Myostatin (a.k.a. growth differentiation factor 8) is a muscle protein that primarily inhibits the growth and differentiation of muscle cells. While this function is important to prevent unregulated hypertrophy and ensure proper healing following injury, there are times when inhibiting myostatin could be of benefit. The ability to stop myostatin from functioning could be useful in conditions like Duchenne muscle dystrophy (DMD) or in people who suffer muscle loss during prolonged immobility. In these cases, inhibiting this natural enzyme could help to slow muscle breakdown, maintain strength, and stave off morbidity.
In mouse models of DMD, it has been found that IGF1 LR3 and other IGF 1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis. IGF1 LR3, thanks to its long half-life, is highly effective in counteracting myostatin and appears to work by activating a muscle protein called MyoD. MyoD is the protein normally activated by exercise (e.g. weight lifting) or tissue damage and is responsible for muscle hypertrophy.

IGF1-LR3 Longevity Research

IGF1 LR3 promotes tissue repair and maintenance throughout the body, making it a protective molecule against cell damage and the effects of aging. Research in cows and pigs indicates that IGF1 LR3 administration may be an effective solution for offsetting the effects of cellular aging. Ongoing research in mice seeks to determine if IGF1 LR3 might be useful in preventing progression of a wide range of conditions such as dementia, muscle atrophy, and kidney disease. This research reveals that IGF 1 administration can prolong life and reduce disability

Glucocorticoid Signaling

Glucocorticoids, secreted primarily by the adrenal glands, are important clinical drugs used to control pain and reduce inflammation in autoimmune diseases, neurological injury, cancer, and more. Unfortunately, glucocorticoids have a number of undesirable side effects such as muscle wasting, fat gain, and deterioration of bone density. There is some interest in using IGF1 LR3 to reduce the side effects of glucocorticoids and thus allow for more effective therapy.

IGF1 LR3 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. IGF1 LR3 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy IGF1 LR3 if you are a licensed researcher.

FAQs – IGF 1 LR3

Q1: What is IGF 1 LR3?
A: IGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3) is a synthetic peptide derived from IGF-1. It has a modified structure that increases its half-life and potency, making it effective for promoting muscle growth, enhancing recovery, and supporting tissue repair in research settings.

Q2: How is IGF 1 LR3 different from regular IGF 1?
A: IGF1 LR3 is a longer-acting version of natural IGF1. It resists binding to IGF-binding proteins and remains active in the body for up to 20–30 hours, compared to IGF-1’s short half-life of about 20 minutes. This extended activity enhances its research utility.

Q3: What is the typical research dosage for IGF 1 LR3?
A: Common research protocols use doses ranging from 20mcg to 100mcg per day, often administered once daily due to its long half-life. The dosage may vary based on the specific study objective.

Q4: What are the potential benefits of IGF 1 LR3 in research?
A: IGF 1 LR3 is studied for its ability to stimulate muscle cell growth (hyperplasia), enhance lean muscle mass, accelerate recovery from injury, and improve insulin sensitivity and cellular repair mechanisms.

Q5: Are there any side effects associated with IGF 1 LR3?
A: In research, potential side effects may include hypoglycemia (low blood sugar), joint pain, water retention, and organ growth if used excessively. It is essential to follow research guidelines closely.

Q6: Is IGF 1 LR3 legal to buy?
A: IGF 1 LR3 is legal for research purposes only in many countries, including the U.S. It is not approved for human consumption or use as a dietary supplement or drug.

Q7: How should IGF 1 LR3 be stored?
A: IGF 1 LR3 should be stored as a lyophilized powder in a cool, dry place (typically refrigerated at 2–8°C). Once reconstituted with bacteriostatic water, it should be used within a specific timeframe (usually 30 days) and kept refrigerated.

Q8: Where can I buy IGF1 LR3 for research?
A: Reputable peptide suppliers like Peptide Sciences, PureRawz, SwissChems, and Biotech Peptides offer IGF 1 LR3 labeled for research use, with lab testing and Certificates of Analysis (COAs) available.