IGF 1 LR3

IGF 1 LR3 (Insulin-like Growth Factor 1 Long Arg3) is a synthetic peptide designed to enhance muscle growth, recovery, and cellular repair. It is a modified version of natural IGF-1 with an extended half-life—lasting up to 20–30 hours compared to the original’s 20 minutes—allowing it to stay active in the body much longer.

IGF 1 LR3 works by mimicking the effects of insulin and stimulating muscle cell proliferation and differentiation. It promotes protein synthesis, improves nutrient absorption, and accelerates tissue regeneration, making it popular in research related to muscle wasting, injury recovery, and performance enhancement. It’s particularly noted for increasing lean muscle mass without the need for large anabolic doses.

IGF 1 LR3 Peptide

IGF 1 LR3 peptide  is a lab-engineered version of insulin-like growth factor 1, modified for enhanced stability and a longer half-life in the body. It is known for its potent effects on muscle cell growth, repair, and regeneration, making it a popular research compound in fields like muscle wasting, recovery science, and anti-aging.

The “LR3” version—Long Arg3—prevents binding to IGF-binding proteins, allowing greater bioavailability and more sustained activity. Researchers often study IGF-1 LR3 for its ability to promote lean muscle gains, improve protein synthesis, and accelerate recovery processes after physical stress or injury.

Important: IGF-1 LR3 peptide is intended for laboratory research use only—not for human or veterinary use.

 IGF 1 LR3 SIDE EFFECTS

IGF 1 LR3 side effects can vary depending on dosage, individual response, and usage protocols. As a research peptide that mimics insulin-like growth factor 1, it may cause several physiological effects, especially if misused.

Commonly reported side effects include:

• Hypoglycemia (low blood sugar)
• Water retention
• Joint pain or muscle soreness
• Nausea or headaches
• Injection site irritation

Potential long-term risks (based on limited data) may involve:

• Disruption of natural growth hormone balance
• Abnormal tissue growth or organ enlargement
• Possible link to tumor growth if misused or used excessively

Because IGF-1 LR3 influences cell growth and division, researchers caution against unsupervised or high-dose experimentation. It is strictly intended for research use only, and not approved for human consumption.

IGF1-LR3 Research

Cell Division

Like IGF-1, IGF1 LR3 is a potent stimulus for cell division and proliferation. Its primary effects are on connective tissues like muscle and bone, but it also promotes cell division in liver, kidney, nerve, skin, lung, and blood tissues. IGF-1 is best thought of as a maturation hormone because it not only promotes cell proliferation, but differentiation as well. IGF-1 causes cells to mature, in other words, so that they can carry out their specialized functions.
Unlike IGF-1, IGF1 LR3 remains in the bloodstream for long periods of time. This property makes IGF1 LR3 a much more potent molecule. A dose of IGF1-LR3 provides approximately three times as much cell activation as a similar dose of IGF-1. Note that IGF1 LR3 and all IGF-1 derivatives do not promote cell enlargement (hypertrophy), but rather promote cell division and proliferation (hyperplasia). In the case of muscle, for instance, IGF1 LR3 does not cause muscle cells to get larger, but it does increase total numbers of muscle cells.

Fat Metabolism and Diabetes

IGF1-LR3 boosts fat metabolism in an indirect manner by binding to both the IGF-1R receptor and the insulin receptor. These actions increase glucose uptake from the blood by muscle, nerve, and liver cells. This results in an overall decrease in blood sugar levels, which then triggers adipose tissue as well as the liver to begin breaking down glycogen and triglycerides. Overall, this produces a net decrease in adipose tissue and a net energy consumption (i.e. net catabolism).

Given its role in reducing blood sugar levels, it should come as no surprise that IGF1 LR3 reduces insulin levels as well as the need for exogenous insulin in diabetes. In most cases, this translates into a 10% decrease in insulin requirements to maintain the same blood sugar levels. This fact may help scientists understand how to decrease insulin doses in individuals who have decreased insulin sensitivity and may even offer insight into preventing type 2 diabetes in the first place.

Impairs Myostatin

Myostatin (a.k.a. growth differentiation factor 8) is a muscle protein that primarily inhibits the growth and differentiation of muscle cells. While this function is important to prevent unregulated hypertrophy and ensure proper healing following injury, there are times when inhibiting myostatin could be of benefit. The ability to stop myostatin from functioning could be useful in conditions like Duchenne muscle dystrophy (DMD) or in people who suffer muscle loss during prolonged immobility. In these cases, inhibiting this natural enzyme could help to slow muscle breakdown, maintain strength, and stave off morbidity.
In mouse models of DMD, it has been found that IGF1 LR3 and other IGF 1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis. IGF1 LR3, thanks to its long half-life, is highly effective in counteracting myostatin and appears to work by activating a muscle protein called MyoD. MyoD is the protein normally activated by exercise (e.g. weight lifting) or tissue damage and is responsible for muscle hypertrophy.

IGF1 LR3 Longevity Research

IGF1 LR3 promotes tissue repair and maintenance throughout the body, making it a protective molecule against cell damage and the effects of aging. Research in cows and pigs indicates that IGF1 LR3 administration may be an effective solution for offsetting the effects of cellular aging. Ongoing research in mice seeks to determine if IGF1 LR3 might be useful in preventing progression of a wide range of conditions such as dementia, muscle atrophy, and kidney disease. This research reveals that IGF 1 administration can prolong life and reduce disability.

Glucocorticoid Signaling

Glucocorticoids, secreted primarily by the adrenal glands, are important clinical drugs used to control pain and reduce inflammation in autoimmune diseases, neurological injury, cancer, and more. Unfortunately, glucocorticoids have a number of undesirable side effects such as muscle wasting, fat gain, and deterioration of bone density. There is some interest in using IGF1 LR3 to reduce the side effects of glucocorticoids and thus allow for more effective therapy.
IGF1 LR3 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. IGF1 LR3 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy IGF1 LR3 if you are a licensed researcher.

Frequently asked questions (FAQs) about IGF 1 LR3 1mg,

What is IGF 1 LR3?

IGF 1 LR3 (Long Arginine 3 Insulin-like Growth Factor-1) is a modified version of the naturally occurring IGF-1 hormone. It features an arginine substitution at position 3 and an additional 13 amino acids at the N-terminus, enhancing its stability and potency. These modifications result in a longer half-life (approximately 20–30 hours) and reduced binding to IGF binding proteins, making it about three times more potent than native IGF 1. ​

How Does IGF 1 LR3 Work?

IGF 1 LR3 binds to IGF 1 receptors on muscle cells, activating pathways like PI3K/Akt/mTOR that promote muscle growth and inhibit muscle breakdown. It also stimulates satellite cells, aiding in muscle repair and regeneration. Additionally, it can mimic insulin’s effects, influencing glucose metabolism and energy utilization. ​

What Are the Potential Benefits?

Reported benefits of IGF 1 LR3 

• Increased muscle mass and strength

• Enhanced fat loss through improved metabolism

• Improved recovery and reduced inflammation

• Potential anti-aging effects on skin and hair

• Improved bone density and joint health

• Better sleep quality​peptide-guide.

Some users also note localized muscle growth at injection sites, though scientific evidence on this is limited. ​

How Is IGF 1 LR3 Administered?

IGF 1 LR3 is typically administered via subcutaneous or intramuscular injection. Common injection sites include the abdomen, thighs, shoulders, and calves. It’s crucial to rotate injection sites to prevent tissue irritation. ​

 What Is the Recommended Dosage?

Dosage can vary based on individual goals and tolerance:​cleanfarma.ca

• Starting Dose: 20–40 mcg per day

• Typical Range: 50–120 mcg per day

• Maximum Recommended: Do not exceed 120 mcg daily​

It’s advisable to start with a lower dose to assess tolerance and gradually increase as needed. ​cleanfarma.ca

What Is the Typical Cycle Length?

A common cycle involves using IGF 1 LR3 for 4 to 6 weeks, followed by a break of equal or longer duration to prevent desensitization. This cycling helps maintain the peptide’s effectiveness and reduces potential side effects. ​

What Are the Potential Side Effects?

Possible side effects include:​

• Hypoglycemia (low blood sugar)

• Joint and muscle pain

• Headaches and nausea

• Injection site irritation

• Potential increased risk of certain cancers with prolonged high-dose use

• Acromegaly-like symptoms (enlarged facial features, hands, or feet) with extended high-dose use​

Monitoring blood sugar levels and adhering to recommended dosages can mitigate some risks. ​

How Should IGF 1 LR3 Be Reconstituted and Stored?

IGF-1 LR3 typically comes as a lyophilized powder and needs to be reconstituted with sterile or bacteriostatic water. After reconstitution, store the solution in a refrigerator and use it within 1–2 months. Always follow sterile procedures during reconstitution and administration.

Is IGF 1 LR3 Legal and Safe?

IGF 1 LR3 is primarily intended for research purposes and is not approved for human consumption in many countries. Its use outside of approved clinical settings may be illegal and carries potential health risks. Always consult with a healthcare professional before considering its use.​

 Final Considerations

While IGF 1 LR3 shows promise in muscle growth and recovery, it’s essential to approach its use with caution. Due to potential side effects and legal considerations, thorough research and professional consultation are crucial before use.