IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic analog of IGF-1 with an extended half-life. It can promote lean mass changes by extending growth factor activity, but comes with significant risks including dangerous blood sugar drops and potential links to cancer progression.

Mechanism of Action

IGF-1 LR3 works by binding to IGF-1 receptors and promoting protein synthesis, cell growth, and muscle development. The ‘Long R3’ modification extends its half-life, making it more potent and longer-lasting than natural IGF-1, but also more unpredictable in its effects.

Benefits

• •Promotes lean muscle mass development
• •Enhanced protein synthesis
• •Improved muscle recovery
• •Extended growth factor activity
• •May improve muscle fiber quality

Side Effects & Negatives

• •Dangerous hypoglycemia (low blood sugar)
• •Potential cancer progression acceleration
• •Organ enlargement risks
• •Joint pain and swelling
• •Injection site reactions
• •Unpredictable blood sugar fluctuations
• •Possible immune system disruption

Safety Profile

Highly unstable and dangerous compound. The risk of severe hypoglycemia can be life-threatening. Links to cancer progression make it particularly concerning for long-term health. Not FDA-approved and considered experimental with limited safety data.

Dosage Information

No established safe dosing protocols exist. Research doses vary widely and carry significant risks. Any use should only be considered under strict medical supervision with continuous glucose monitoring.

Research Studies

• 1. Yakar et al. (2005): ‘The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models’ – Well-known review clearly outlining the connection between the IGF-1 pathway and cancer risk, emphasizing that many cancers overexpress the IGF-1 receptor and citing epidemiological data showing elevated serum IGF-I levels are associated with increased risk of epithelial cancers
• 2. Multiple studies have documented the role of IGF-1 in both muscle growth and cancer cell proliferation, highlighting the dual-edged nature of this growth factor