Gonadorelin 10mg is a synthetic form of gonadotropin-releasing hormone (GnRH), designed to mimic the natural hormone released by the hypothalamus. It stimulates the anterior pituitary gland to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH), both critical for regulating reproductive function in both men and women.
Clinically, Gonadorelin is used to assess pituitary function and to treat reproductive hormone deficiencies, delayed puberty, or infertility-related conditions. In performance enhancement and research contexts, it is often employed to restore natural testosterone production, especially following prolonged anabolic steroid use or suppression of natural hormone levels.
This 10mg formulation is typically available as a lyophilized powder for reconstitution and is administered via subcutaneous or intramuscular injection under professional supervision.
Key Features:
- Synthetic GnRH analog
- Stimulates LH and FSH release
- Used in fertility treatments and hormonal assessments
- Supports testosterone recovery post-cycle
- Formulation: Usually comes in lyophilized powder (e.g., 10mg vial) and must be reconstituted with bacteriostatic water.
- Supervision: Gonadorelin use, especially outside clinical settings, should be closely monitored due to hormonal impact and potential for desensitization with overuse.
- Storage: Once reconstituted, store refrigerated and use within the recommended timeframe.
Gonadorelin Dosage
The appropriate dosage of Gonadorelin depends on its intended use—whether for diagnostic purposes, hormone therapy, fertility treatment, or post-cycle therapy (PCT) in performance enhancement settings. Below is a breakdown by context:
1. Clinical (Diagnostic) Use
- Purpose: To test pituitary function (LH/FSH response)
- Typical Dose:
- 0.1 mg (100 mcg) administered IV or SC as a single dose
- Response Time: Blood samples are usually taken at 15, 30, 45, and 60 minutes post-injection to measure LH/FSH levels.
2. Therapeutic Use (e.g., Hypogonadism, Infertility)
- Typical Dose:
- 5–20 mcg administered IV or SC every 90–120 minutes (pulsatile pump delivery)
- Note: Pulsatile dosing is crucial for mimicking natural GnRH release and stimulating proper LH/FSH secretion.
3. Research or Performance Enhancement (PCT after Steroid Use)
- Typical Dose:
- 100–250 mcg per day, typically subcutaneously, for 7–14 days
- Goal: Restart endogenous testosterone production by stimulating LH/FSH after exogenous suppression.
4. Female Fertility Protocols (Less Common)
- Used off-label in some IVF protocols but typically replaced with longer-acting GnRH analogs.
Important Considerations
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Formulation: Usually comes in lyophilized powder (e.g., 10mg vial) and must be reconstituted with bacteriostatic water.
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Supervision: Gonadorelin use, especially outside clinical settings, should be closely monitored due to hormonal impact and potential for desensitization with overuse.
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Storage: Once reconstituted, store refrigerated and use within the recommended timeframe.
Gonadorelin Dosage for Men
Gonadorelin is used in men primarily for two purposes:
- To assess pituitary function (diagnostic use)
- To stimulate natural testosterone production (therapeutic or post-cycle therapy use)
Here’s how dosing varies based on the goal:
1. Diagnostic Use (Pituitary Function Test)
- Dose: 100 mcg (0.1 mg) IV or SC, single dose
- Purpose: To test if the pituitary can properly release LH and FSH in response to GnRH
- Protocol: Blood samples are drawn before and at intervals after the injection (typically 15, 30, 45, 60 minutes) to measure LH and FSH response.
2. Testosterone Recovery / Post-Cycle Therapy (PCT)
This is off-label use but common in bodybuilding or hormone recovery contexts.
- Dose: 100–250 mcg subcutaneously once per day
- Duration: 7 to 14 days is typical, though some protocols extend to 21 days
- Purpose: To “jumpstart” the hypothalamic-pituitary-gonadal (HPG) axis after suppression from anabolic steroid use
3. Infertility Treatment or Hypogonadotropic Hypogonadism
- Dose: 5–20 mcg IV or SC every 90–120 minutes via a pulsatile infusion pump
- Duration: Long-term (weeks to months)
- Goal: Mimic natural GnRH pulsatility to stimulate LH/FSH and restore spermatogenesis/testosterone production
This is a very specialized protocol and typically only done in fertility clinics under endocrinologist supervision.
Key Guidelines
- Reconstitution: Typically comes in a 10mg lyophilized vial, diluted with bacteriostatic water
- Injection route: Subcutaneous is most common for daily use; IV reserved for diagnostic testing
- Storage: Keep reconstituted solution refrigerated and use within 14–30 days (depending on preparation)
- Reconstitute 10mg vial with 2mL bacteriostatic water
- Final solution = 5mg/mL (5000 mcg/mL)
- Dose: 100–250 mcg per day
- Route: Subcutaneous injection (e.g., in the abdomen or thigh)
- Frequency: Once daily
- Duration: 7–14 days, sometimes up to 21 days depending on suppression levelFor 150 mcg dose: use 0.03 mL (30 IU on insulin syringe)
Gonadorelin Dosage for Bodybuilding
In the bodybuilding world, Gonadorelin is used off-label to help restore natural testosterone production after a cycle of anabolic steroids. Here’s what you need to know:
Purpose in Bodybuilding
- Reactivate the hypothalamic-pituitary-gonadal (HPG) axis
- Stimulate LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone)
- Support natural testosterone production
- Avoid long-term suppression and testicular atrophy
Common Dosage Protocol
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Dose: 100–250 mcg per day
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Route: Subcutaneous injection (e.g., in the abdomen or thigh)
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Frequency: Once daily
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Duration: 7–14 days, sometimes up to 21 days depending on suppression level
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Typical PCT Stack Example (Informational Only)
Compound Dose Duration Gonadorelin 150 mcg daily SC 10–14 days HCG (optional) 500–1000 IU 2–3x/week 2 weeks Clomid 25–50 mg/day 4 weeks Nolvadex 20 mg/day 4 weeks Note: Not everyone stacks all these; combinations vary based on the severity of suppression, previous cycle length, and individual response.
Tips for Bodybuilders Using Gonadorelin
- Use short-term only to avoid desensitization
- Don’t exceed 250 mcg/day
- Best used immediately post-cycle when HPTA function is most suppressed
- Combine with SERMs (like Clomid/Nolvadex) for a more effective restart
Mixing Instructions (if using 10mg vial)
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Reconstitute 10mg vial with 2mL bacteriostatic water
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Final solution = 5mg/mL (5000 mcg/mL)
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For 150 mcg dose: use 0.03 mL (30 IU on insulin syringe)
FAQs: Gonadorelin 10mg
1. What is Gonadorelin 10mg used for?
Gonadorelin 10mg is used to stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. It’s commonly used to diagnose pituitary function, treat hormone deficiencies, and support fertility. In bodybuilding, it’s used to help restore natural testosterone production post-cycle.
2. How is Gonadorelin 10mg administered?
Gonadorelin is typically reconstituted with bacteriostatic water and administered via subcutaneous (SC) or intravenous (IV) injection, depending on the intended use.
3. What is the typical dosage for Gonadorelin 10mg in post-cycle therapy (PCT)?
For PCT or hormone recovery:
- 100–250 mcg per day
- Subcutaneously, once daily
- Duration: 7 to 14 days
Longer use is not recommended due to the risk of receptor desensitization.
4. Can Gonadorelin help increase testosterone levels naturally?
Yes. Gonadorelin stimulates the pituitary to release LH and FSH, which in turn trigger the testes to produce testosterone. This makes it valuable for men recovering from anabolic steroid use or with suppressed testosterone levels.
5. Are there any side effects of using Gonadorelin?
Possible side effects include:
- Headache
- Nausea
- Flushing
- Abdominal discomfort
- Hormonal imbalance if overused
Prolonged or high dosing can lead to desensitization of GnRH receptors, reducing effectiveness.
6. Do I need a prescription to use Gonadorelin 10mg?
Yes, in most countries, Gonadorelin is a prescription-only medication, especially when used for fertility or hormone therapy. However, it’s sometimes available through research chemical suppliers (off-label use is at your own risk).
7. How should I store Gonadorelin 10mg after reconstitution?
- Before reconstitution: Store in a cool, dry place
- After reconstitution: Keep refrigerated (2°C–8°C / 36°F–46°F)
- Use within 14–30 days, depending on the diluent and storage conditions
8. Can Gonadorelin be used alongside other PCT compounds like HCG or Clomid?
Yes. Many protocols combine Gonadorelin with HCG, Clomid, or Nolvadex to maximize hormone recovery. However, it should be done carefully to avoid overstimulation or conflicting signals to the HPTA.
Jonathan Parker –
Used for hormone support—restored balance and felt more energized.
Emily Bennett –
Regulated LH levels better than previous compound I tried. Clean product
Matthew Ross –
High purity and great potency. No side effects observed.
Heather Young –
Effective for triggering natural hormonal response. Will continue using in research