GHK Cu 200 mg

GHK Cu 200 mg is a naturally occurring tripeptide (Gly‑His‑Lys) tightly bound to a copper ion. Present in young, healthy plasma at ~200 ng/mL and declining with age, this peptide‑copper complex acts as a potent regenerative signal in skin, hair follicles, and connective tissues.

Key Benefits:

• Anti‑Aging & Skin Rejuvenation
  Stimulates collagen, elastin, and glycosaminoglycan synthesis in dermal fibroblasts—resulting in firmer, denser skin with reduced fine lines, wrinkles, and hyperpigmentation.

• Wound Healing & Tissue Repair
  Accelerates wound closure, promotes angiogenesis, and balances matrix metalloproteinases—demonstrated in animal and human studies.

• Anti‑Inflammatory & Antioxidant Effects
  Reduces oxidative stress and inflammatory cytokines, while attracting immune and endothelial cells to support tissue repair.

• Hair Growth Promoter
  May prolong the anagen phase of hair, increase follicle size, and thicken strands—effects comparable to low-dose minoxidil in some studies.

Scientific Backing & Efficacy:
Clinical trials show that daily topical use for 12 weeks significantly improves skin elasticity, clarity, and wrinkle depth—outperforming standard retinoids and vitamin C formulations . Preclinical research also confirms its efficacy in tissue protection, gene expression modulation, and anti-aging pathways .

Suggested Use & Dosage:

• Topical Serums & Creams: Often formulated at 2%–10%, with 4% being optimal for routine use. ~50 mg per application equates to ~¼ tsp.

• Injectables: Clinical preparations typically offer 10 mg/mL for localized treatments—should only be used under professional.

Safety Profile:
Generally well-tolerated in topical applications; mild irritation is rare. Systemic or oral use should be cautious—excessive copper intake may cause gastrointestinal discomfort or toxicity.

Ideal For:

• Mature skin needing structural support and repair

• Enhancing skin tone, texture and elasticity

• Boosting recovery from injury, scarring, or post-procedure damage

• Improving hair density and scalp health

Why Choose GHK‑Cu 200 mg?

This concentrated formulation delivers a therapeutic dose of the gold-standard copper peptide—supporting potent regenerative, anti-inflammatory, and structural benefits backed by decades of scientific study. Ideal for formulators developing serums, creams, microneedling boosters, or professional-grade injectables.

GHK‑Cu 50 mg Dosage

Standard Reconstitution

• Add ~1 mL bacteriostatic water to a 50 mg vial → yields ~50 mg/mL concentration.

• Some protocols recommend adding 3 mL instead for more flexible dosing (~16.7 mg/mL)

 Recommended Daily Injection (Subcutaneous)

• 1 mg/day (Week 1–4): ~0.02 mL from 50 mg/mL or ~6 units from 16.7 mg/mL reconstitution

• 2 mg/day (Week 5–8): ~0.04 mL from strong solution or ~12 units from diluted solution .

• Alternate simple approach: 10 units daily from 50 mg vial lasts ~20 days (~2.5 mg/day).

• Another common regimen: 0.2 mL/day of 50 mg/mL (equals 10 mg/day), though this is higher than typical and must be clinician‑supervised .

Cycle Length & Tapering

• Typical cycles: 8–12 weeks total .

• Some protocols suggest 3 weeks on (at ~2.5 mg/day) then pause; others apply 8 weeks continuous .

Benefits at These Levels

• Supports collagen and elastin synthesis, wound repair, anti-inflammatory effects, and skin/hair rejuvenation.

Safety & Side Effects

• Usually well-tolerated; mild irritation at injection sites, occasional headache or nausea peptideonlineshop.com.

• Avoid in pregnancy, breastfeeding, or copper‑metabolism disorders like Wilson’s disease .

• Self‑injection carries infection risk—sterile technique is critical.

Sample Dosing Protocol (50 mg vial reconstituted at 16.7 mg/mL)

• Reconstitute: 3 mL bacteriostatic water

• Store reconstituted vial refrigerated; discard after ~30 days

• Use small insulin syringes (30–50 units) for accuracy peptideonlineshop.com.

Summary

• Standard dose: 1–2 mg SC daily.

• Protocol duration: 8–12 weeks or as advised.

• Alternative higher dose: 10 mg/day (0.2 mL of 50 mg/mL solution), for clinical use only.

• Always consult a healthcare provider for tailored guidance.

GHK Research

1. GHK Suppresses Fibrinogen Synthesis

Fibrinogen consists of three polypeptide chains; alpha, beta, and gamma. GHK strongly suppresses the gene for the beta chain of fibrinogen. A lack of adequate FGB will effectively stop fibrinogen synthesis since equal amounts of all three polypeptide chains are needed to produce fibrinogen.

GHK also suppresses the production of the inflammatory cytokine interleukin-6 (IL-6) which is a main positive regulator of fibrinogen synthesis, through its interaction with fibrinogen genes. In cell culture systems, GHK suppresses IL-6 secretion in skin fibroblasts and IL-6 gene expression in SZ95 sebocytes. In summary, the effects of GHK on the FGB gene plus its effects on IL-6 production imply a suppression of overall fibrinogen production.

2. GHK Activates the Ubiquitin/Proteasome System (UPS)

The UPS removes damaged proteins. Higher activities of the UPS appear to delay aging effects. GHK stimulated gene expression in 41 UPS genes while suppressing only 1 UPS gene.

3. GHK Activates DNA Repair Genes

DNA damage is promptly repaired in young and healthy cells, however, as we age, DNA damage starts accumulating. Resetting activity of DNA repair genes can diminish deleterious effects of aging. GHK was primarily stimulatory for DNA repair genes (47 UP, 5 DOWN).

4. GHK Acts as an Antioxidant

Free radicals and toxic end products of lipid peroxidation are linked to atherosclerosis, cancer, cataracts, diabetes, nephropathy, Alzheimer’s disease and other severe pathological conditions of aging. GHK stimulates 14 antioxidant genes and suppresses two pro-oxidant genes.

5. GHK Suppresses Insulin and Insulin-Like Genes

The insulin family has been proposed as a negative controller of longevity; higher levels of insulin and insulin-like proteins reduce lifespan. GHK stimulates 3 genes in this system and suppresses 6 genes.
The insulin/IGF-1- like receptor pathway is a contributor to the biological aging process in many organisms. The gene expression data suggests that GHK suppresses this system, as 6 of 9 of the affected insulin/IGF-1 genes are suppressed. Insulin/IGF-1-like signaling is conserved from worms to humans. In vitro experiments show that mutations that reduce insulin/IGF-1 signaling have been shown to decelerate the degenerative aging process and extend lifespan in many organisms, including mice and possibly humans. Reduced IGF-1 signaling is also thought to contribute to the “antiaging” effects of calorie restriction.

6. GHK Repairs Tissue by TGF Superfamily

The most explored of GHK’s actions is the repair of damaged tissues (skin, hair follicles, stomach and intestinal linings, and boney tissue) either by the use of copper-peptide-containing creams or by induction of systemic healing.

Campbell et al. found that GHK’s resetting of gene expression of fibroblasts from COPD patients fits into this category of tissue repair via the TGF beta superfamily. Campbell et al. also found that GHK directly increases TGF beta and other family members which activate the repair process.

7. Cancer Controlling Genes

Caspase, growth regulatory, and DNA repair genes are important in cancer suppression. In 2010, Hong et al. identified 54 genes associated with aggressive, metastatic, human colon cancer. The Broad Institute’s Connectivity Map was used to find compounds that reverse the differential expressions of these genes. The results indicated that two wound healing and skin remodeling molecules, GHK at 1 micromolar and securinine at 18 micromolar, could significantly reverse the differential expression of these genes and suggested that they may have a therapeutic effect on the metastasis-prone patients.

Conclusion

The tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, and boney tissue), increases collagen and glycosaminoglycans, stimulates synthesis of decorin, increases angiogenesis, and nerve outgrowth, possesses esses antioxidant and anti-inflammatory effects, and increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells. Recently, GHK has even been found to reset genes of diseased cells from patients with cancer or COPD to a healthier state.

GHK exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. GHK for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy GHK if you are a licensed researcher.