Decapeptide

Decapeptide is a powerful, laboratory-engineered chain of ten amino acids designed to deliver targeted skincare and therapeutic benefits. Known for its remarkable ability to influence cellular communication, Decapeptide helps improve skin texture, reduce inflammation, and enhance the production of collagen and elastin. It is commonly used in advanced cosmetic formulations for anti-aging, pigmentation control, and skin repair. Suitable for topical use in serums, creams, and aesthetic treatments, Decapeptide is a go-to ingredient for promoting youthful, even-toned, and revitalized skin.

Decapeptide 12 200mg

Decapeptide 12 is an oligopeptide with well-known anti-tyrosinase activity. It is under active investigation for its ability to help improve both skin tone and skin texture. Tyrosinase is a copper-containing enzyme found widely in plant and animal tissues. It catalyzes the production of melanin and other pigments. By interfering with tyrosinase, decapeptide 12 is able to lighten skin tone in animal models.

Research Application

Tyrosinase is an enzyme essential to the production of melanin and other pigments. A deficiency of tyrosinase results in type I oculocutaneous albinism while any mutation that causes tyrosinase to be overactive will lead to hyperpigmentation of the skin secondary to melanin production. Both the medical and cosmetics industries are interested in tyrosinase inhibitors, like decapeptide 12, as both therapeutics and to help better clarify how the enzyme cascade of pigment production works.
The food industry has also investigated decapeptide-12 as a potential preservative and flavor enhancer. Tyrosinase catalyzes the oxidation of phenolic compounds found in fruits and vegetables (it is what turns potatoes black after they are cut) to quinones. This conversion gives food an unpleasant taste and color. It also makes it harder for certain proteins to be digested and thus decreases the nutritional value of food.
Tyrosinase has a number of unique roles in the insect world. It can affect wound healing, parasite encapsulation, and the formation of an insect’s hard exosekleton. Inhibitors of tyrosinase, like decapeptide 12, have been studied as potential insecticides.

What Is Decapeptide 12

Decapeptide 12 is a small oligopeptide made of just twelve amino acids (Tyr-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr). It is primarily known for its ability to inhibit activity of the tyrosinase enzyme responsible for producing melanin.

What Does Decapeptide 12 Do?

Decapeptide 12 reversibly binds to tyrosinase, an enzyme found in a number of different pigment-producing cells. It prevents tyrosinase from catalyzing the oxidation of phenols, the first step in melanin production. In mammals, tyrosinase is found only in melanosomes, special compartments within pigment-producing cells. Tyrosinase is not preserved across species and, in fact, can differ drastically in structure even among closely-related species. In humans, differences in the efficiency of tyrosinase determine skin color and are the result of slight modifications in the TYR gene found on chromosome 11.

Decapeptide 12 Research and the Lightening of skin Tone

A prospective animal study study looking at the safety and efficacy of topical decapeptide 12 in photodamage found that decapeptide 12 reduces skin pigmentation dramatically. In fact, nearly 40% of subjects in the study achieved baseline skin tone (100% reduction in hyperpigmentation) and 15% moved from grade 3 photodamage to grade 1 photodamage. Those with the most severe photodamage (grade 4) experienced only moderate improvement to grade 3 after twelve weeks of use.
In a split-face (one side of the face is given one product and the other side is given another product), randomized, double-blind and placebo controlled pilot study, statistically significant changes in skin tone were seen in 100% of subjects suffering from melasma (photdamage).
Decapeptide-12 is approximately 17 times more potent than previous treatments for hyperpigmentation, including hydroquinone. Studies in cultured melanocytes over 7 days demonstrated a 27%-43% reduction in melanin content. Decapeptide-12 has undergone multiple animal trials and may eventually be included in commercial products for treating hyperpigmentation.

Decapeptide 52

Decapeptide 52 is a synthetic peptide composed of ten amino acids, specifically developed for its potent skin-calming and anti-inflammatory properties. Widely used in advanced dermatological and cosmetic formulations, Decapeptide-52 helps reduce redness, irritation, and sensitivity, making it ideal for sensitive or reactive skin types. It works by modulating the skin’s inflammatory response, reinforcing the skin barrier, and promoting faster recovery after aesthetic procedures. Decapeptide-52 is often included in post-treatment serums, soothing creams, and sensitive skincare lines to enhance skin comfort, resilience, and overall health.