BPC 157

COA BPC 157 Certificate

BPC 157 (Body Protection Compound-157) is a synthetic peptide derived from a protective protein found in the human gastric system. It is widely studied for its regenerative properties and is believed to support accelerated healing in muscles, tendons, ligaments, and the gastrointestinal tract. Researchers are particularly interested in its potential to promote angiogenesis (new blood vessel formation), reduce inflammation, and protect organs under stress.

This pentadecapeptide (15 amino acids) remains stable in human gastric juice, making it a unique subject of gastrointestinal and musculoskeletal research. It’s non-toxic in various experimental models and has shown promise in promoting recovery from injuries that typically heal slowly.

HPLC BPC 157 Certificate

MS BPC 157 Certificate

 

Synthetic BPC 157, a pentadecapeptide comprising 15 amino acids isolated from the much larger BPC protein, has been found to retain many of the healing properties of its parent molecule. In particular, BPC 157 has been shown to have effects on:

• Wound healing
• Blood vessel growth
• The coagulation cascade
• Nitric oxide generation
• Immune system function
• Gene expression
• Hormone regulation (particularly in the gastrointestinal nervous system)

BPC 157 Peptide Research

1. BPC 157 and Wound Healing

The natural function of BPC in the Gl tract is to maintain the integrity of the mucosal barrier that protects underlying tissues from the harmful actions of gastric acid, bile, and other compounds necessary for digestion and absorption of nutrients from food. At least part of this function is mediated through the recruitment of fibroblasts. BPC 157 has a dose-dependent effect on the spread of fibroblasts in culture and in vivo, causing the cells to both proliferate and migrate faster. Fibroblasts are integral to wound healing as they are the cells responsible for laying down extracellular matrix proteins like collagen, fibrin, elastin, and more.

2. Vascular Growth and Collateralization

BPC 157 is a potent angiogenic factor, increasing the rate at which endothelial cells (the cells that line blood vessels) proliferate and grow. Research in rats shows that the peptide substantially increases the rate of collateral blood vessel growth in the setting of ischemia. While this effect has been primarily observed in the Gl tract, there is evidence for similar benefit in cardiovascular, neurological, and muscle tissues, suggesting that BPC 157 may be used as both a therapy in the setting of stroke and heart attack as well as a probative peptide for understanding how to promote healing following ischemic injury. Studies in chicken embryos suggest that at least part of the mechanism by which BPC 157 promotes vascular growth is through the stimulation of VEGFR2, a cell surface receptor active in the nitric oxide signaling pathway. VEGFR2 is thought to play an important role in endothelial cell growth, proliferation, and longevity.

Cell culture research has effectively demonstrated vascular “running” secondary to BPC 157 administration. Vascular running is the process by which vessels grow toward an area of injury or around an area of vascular occlusion to reestablish blood flow to distal tissue and protect cell function. This particular function of BPC 157 may make it possible to develop an effective oral treatment for slow-growing arterial occlusions, such as are seen in atherosclerotic heart disease. This area of research may one day render unnecessary surgical interventions such as stenting, coronary artery bypass grafting, and more.

3. BPC 157 and Tendon Healing

Given its roles in fibroblast recruitment and blood vessel growth, it should come as no surprise that BPC 157 has shown positive findings in animal models of tendon, ligament, bone, and other connective tissue injuries. Tendon and ligament injuries are slow to heal, in large part, due to poor blood supply in these tissues. Poor blood supply slows the rate at which fibroblasts and other wound-healing cells can reach the area of injury and, ultimately, restricts the overall level of repair that can take place. Both in vitro and in vivo research involving rat tendons has shown that BPC 157 promotes collateralization and boosts fibroblast density in the setting of tendon, ligament, and bone injury. This research indicates that BPC 157 is more effective than bFGF, EFG, and VGF hormones in promoting healing in these tissues.

Experiments using FITC-phalloidin staining have revealed that BPC 157 is a potent stimulator of F-actin formation in fibroblasts. F-actin is critical to cell structure and function, playing an important role in cell migration. Analysis via western blotting indicates that BPC 157 increases phosphorylation of paxillin and FAK proteins, which are critical proteins in the cell migration pathway.

4. Antioxidant Properties

Research in rats has shown that BPC 157 can neutralize certain oxidative stress markers like nitric oxide and malondialadehyde (MDA). This makes BPC 157 a powerful antioxidant, a property of the peptide that is further supported by research showing that it can reduce the production of reactive oxygen species in the gastrointestinal tract. Research investigating whether modified lactococcus lactis bacteria can deliver BPC 157 to the Gl system shows that the bacteria increases levels of the peptide dramatically in cell culture.

5. BPC 157 and Drug Side Effects

Often, the limiting factor in medical pharmaceutical use is side effects. NSAIDs, like ibuprofen, for instance, cannot be used for long periods of time because they increase gastric bleeding as well as the risk for heart attack. The ability to counteract side effects while leaving desired effects intact is a holy grail of modern medical research as it would improve therapeutic benefits for a number of drugs. BPC 157 has been found to counteract side effects of NSAIDs, medications used in psychiatric conditions, and a number of heart medications.

It should come as no surprise that BPC 157 helps to prevent many of the Gl side effects that certain drugs are known for, but it is less intuitive that the peptide also protects against side effects in the brain, heart, and other tissues. Research in rats, for instance, shows that BPC 157 can protect against QTc prolongation in the heart, a condition that can lead to serious and even fatal arrhythmias. QTc prolongation is caused by drugs used to treat diabetes, schizophrenia, and other psychiatric conditions . Similarly, BPC 157 has been shown to prevent other side effects of psychiatric medications, including severe side effects like catalepsy and somatosensory disturbance. This latter benefit may make it possible to more adequately treat psychiatric conditions, which are notoriously difficult to treat, in part because patients often discontinue their medications secondary to severe side effects.

6. BPC 157 and Bees

Colony collapse disorder (CCD) is a syndrome in which entire colonies of honey bees experience rapid decline and, eventually, complete destruction. Causes of the condition are not fully defined, but at least part of the problem can be contributed to an infection in honey bee guts by the fungus Nosema ceranae. By supplementing the food that honey bees eat with BPC 157, researchers have shown a reduction in the damage the fungus causes in honey bee Gl tracts and a concomitant increase in hive survival rates. These trials were carried out in natural field settings and offer the first significant oral treatment for reducing the impact of CCD on the most important pollinator for most food crops.

Future BPC 157 Research

BPC 157 is under active investigation in a number of cell culture and animal models. The peptide shows a great deal of promise not just as therapeutic agent for promoting wound healing and regulating vascular growth, but as a tool for investigating these processes to better understand their control. Research using BPC 157 has the potential to shed a great deal of light on angiogensis in particular, a process that is not only critical to wound healing, but that plays extensive roles in growth, cancer development, and embryogenesis.

BPC 157 exhibits minimal side effects, moderate oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. BPC 157 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy BPC 157 if you are a licensed researcher.

BPC 157 Benefits 

BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a naturally occurring protein found in human gastric juice. In preclinical and animal studies, it has demonstrated a wide range of healing and regenerative properties, making it a subject of growing interest in the fields of musculoskeletal and gastrointestinal research.

Key Potential Benefits of BPC 157 (Based on Preclinical Studies):

• Accelerated Healing of Muscles, Tendons, and Ligaments:
  Shown to promote tissue repair and regeneration in soft tissue injuries, including tendon ruptures and muscle tears.
• Supports Joint and Bone Recovery:
  May aid in healing damaged joints and bones by promoting collagen synthesis and enhancing cell migration.
• Gastrointestinal Protection:
  Helps protect and repair the gut lining, making it of interest for conditions like ulcers, IBS, and inflammatory bowel disease in animal models.
• Improved Blood Vessel Formation (Angiogenesis):
  Stimulates new blood vessel growth, which aids in faster healing and improved nutrient delivery to damaged tissues.
• Neuroprotective Effects:
  Early research suggests potential in reducing damage from brain injuries or nerve trauma by supporting neural regeneration.
• Anti-Inflammatory Action:
  Reduces inflammation and oxidative stress at injury sites, contributing to quicker recovery.
• Organ Protection:
  Shown to help protect the liver, pancreas, and heart under stress conditions in animal studies.

Important Reminder:

These benefits are based primarily on animal studies and laboratory research. BPC-157 has not been approved for human use, and its effectiveness and safety in humans have not been confirmed through clinical trials. It is sold strictly for research purpose

BPC 157 Peptide 

BPC 157 (Body Protection Compound-157) is a synthetic peptide made up of 15 amino acids (a pentadecapeptide), derived from a protective protein found in human gastric juice. It has gained attention in scientific and medical research circles for its powerful tissue-regenerating and anti-inflammatory properties observed in preclinical studies.

What Is BPC 157 Peptide Used For in Research?

BPC-157 is being studied for its potential to:

• Accelerate healing of muscles, tendons, ligaments, and nerves
• Promote repair of the gut lining and support GI health
• Enhance wound healing and post-surgical recovery
• Stimulate angiogenesis (formation of new blood vessels)
• Reduce inflammation and protect internal organs under stress
• Provide neuroprotective benefits in cases of nerve damage

These effects have been well-documented in rodent models, making BPC-157 a focus of ongoing research in regenerative medicine and sports science.

Scientific Characteristics:

• Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
• Form: Lyophilized powder for reconstitution
• Stability: Highly stable in gastric environments
• Solubility: Water-soluble

Important Disclaimer:

BPC-157 peptide is not approved for human consumption or therapeutic use. It is intended strictly for research and laboratory use. No claims are made regarding its efficacy or safety in humans, and any such use is considered experimental.

BPC-157 – Frequently Asked Questions (FAQs)

1. What is BPC 157?
BPC 157 (Body Protection Compound-157) is a synthetic peptide made of 15 amino acids. It is derived from a protein found in human gastric juice and is studied for its regenerative and healing properties in preclinical research.

2. What is BPC 157 used for in research?
BPC 157 is primarily studied for:

• Healing of tendons, ligaments, and muscles
• Gastrointestinal tract protection and repair
• Nerve regeneration
• Wound healing and angiogenesis (blood vessel formation)
• Organ protection under stress conditions

3. Is BPC 157 approved for human use?
No. BPC 157 is not approved by the FDA or other major regulatory agencies for human consumption or therapeutic use. It is sold strictly for research and laboratory purposes.

4. Are there any known side effects of BPC 157?
In animal studies, BPC 157 has shown a strong safety profile with low toxicity. However, because it hasn’t undergone clinical trials in humans, potential side effects remain unknown. Some anecdotal reports mention headaches, dizziness, and blood pressure changes, but these are unverified.

5. How is BPC 157 typically administered in research?
In laboratory settings, BPC 157 is usually administered via:

• Subcutaneous injection
• Intramuscular injection
• Oral application (not common but studied due to its gastric stability)

6. Can BPC 157 heal joint or tendon injuries?
In rodent models, BPC 157 has demonstrated significant potential to accelerate the healing of soft tissues like tendons and joints. However, no human clinical trials confirm its efficacy in treating such injuries in people.

7. Is BPC 157 legal to buy?
Yes, BPC 157 can be legally purchased in many countries for research use only. However, selling or marketing it for human consumption is prohibited and may violate regulatory guidelines.

8. What makes BPC 157 unique compared to other peptides?
BPC 157 is highly stable in gastric juice, shows a wide range of tissue-healing capabilities, and appears to have systemic effects across multiple organ systems in animal models. Its ability to promote angiogenesis and protect the gut lining distinguishes it from many other peptides.

9. Does BPC 157 affect hormones?
There is no conclusive evidence showing that BPC 157 significantly alters hormone levels. Most studies focus on its regenerative and anti-inflammatory properties, but hormonal effects have not been ruled out due to the lack of human trials.

10. Is BPC 157 the same as TB-500 or other healing peptides?
No. While both BPC 157 and TB-500 (Thymosin Beta-4) are studied for tissue repair, they have different origins, structures, and mechanisms of action. BPC-157 is derived from the stomach lining, while TB-500 is based on a natural actin-sequestering protein.