5-Amino-1MQ

5 Amino 1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism and energy regulation. It enhances metabolism leading to steady fat loss and improved energy levels.

Mechanism of Action

5-Amino-1MQ works by inhibiting NNMT, which leads to increased NAD+ levels and enhanced cellular energy metabolism. This results in improved mitochondrial function, increased fat oxidation, and reduced fat storage.

Benefits

• •Enhanced metabolism and steady fat loss
• •Improved energy levels throughout the day
• •Increased NAD+ levels supporting cellular health
• •Steady body fat reduction over time
• •May improve insulin sensitivity

Side Effects & Negatives

• •Headaches (most commonly reported)
• •Gastrointestinal discomfort
• •Mild nausea in some users
• •Individual tolerance varies significantly
• •Limited long-term safety data available

Safety Profile

Not FDA-approved for human use. Limited clinical trials in humans. Most safety data comes from animal studies. Side effects are typically mild compared to other fat loss compounds. Still unapproved but considered safer than most alternatives.

Dosage Information

Research dosing: 50-100mg daily. No established human therapeutic dose. Most users report effectiveness at lower doses. Dosing protocols vary widely in research settings.

Research Studies

• 1. Neelakantan et al. (2018): Demonstrated that 5-amino-1MQ significantly reduced body weight and white adipose mass in diet-induced obese mice
• 2. Dimet-Wiley et al. (2022): Combined NNMT inhibition with reduced-calorie diet promoted dramatic weight loss and normalized body composition in obese mice

5 amino 1mq supplement

5 Amino 1MQ is a cutting-edge metabolic compound under investigation for its potential to enhance energy use, support fat reduction, and bolster cellular health via NNMT inhibition and NAD⁺ elevation. Still in experimental stages—with limited human data—it holds promise but demands caution. Not approved for human consumption, its actual effects on people remain uncertain.

What It’s Supposed to Be

5 Amino 1MQ (5-amino-1-methylquinolinium) is primarily described as a research compound, not a regulated supplement, and most reputable sources emphasize that it’s sold “for research use only.

Mechanism of Action

• It inhibits the enzyme nicotinamide N-methyltransferase (NNMT)—which plays a key role in fat cell metabolism.

• By blocking NNMT, it’s said to elevate NAD⁺, enhancing mitochondrial function, energy expenditure, fat breakdown, metabolic rate, and insulin sensitivity.

Claimed Benefits

• Fat loss & improved body composition: Preclinical studies show promise—like in mice—where fat mass reduced without changes in diet.  bodyshock.pro

• Muscle support and recovery: In aged mice, it reportedly improved muscle strength and recovery.

• Metabolic effects: Better insulin sensitivity, energy, possible cholesterol regulation, and anti-aging markers like SIRT1 activation.

• Mental clarity? Some articles even tout cognitive and mood benefits via presumed dopamine effects—though these are speculative. Qafic

Safety, Use & Reality Check

Regulatory Disclaimer

• Not FDA-approved for human use—it’s sold as a “research chemical.”

• That means quality control is inconsistent—purity, dosage, and contamination are real concerns.

Side Effects (from anecdotal reports)

• Users often report mild headaches, nausea, digestive discomfort, insomnia (especially if taken late), and fatigue. PEN PEPTIDE

• Rarely, higher pulses or temporary exercise fatigue.

Users Speak

• Many describe steady energy without jitters or crashes.

• Some saw instinctual benefits like a 7% body mass reduction in mice—but humans? Nothing proven.

• Others flagged scams or lack of results—not everyone sees benefits, and prices are steep.

Dosing Notes (mostly from anecdotal or speculative sources)

• Common capsule dosages: 50 mg/day, sometimes up to 150 mg/day, often cycled (e.g., 4–8 weeks on, 2–4 weeks off).

• Animal studies used higher relative doses (~3.5 mg/kg, equating to ~245 mg daily for a 70kg person), meaning human use is often underdosed compared to those models.

Cost Reality

• Users report prices ranging from $150–$250 for a 60-capsule bottle—expensive.

• And if optimal dosage is higher, one bottle might not even last a month.

NAMPT Inhibitor 

A NAMPT inhibitor refers to any compound that blocks the activity of Nicotinamide Phosphoribosyltransferase (NAMPT), a key enzyme in the NAD+ salvage pathway. NAMPT is responsible for converting nicotinamide (a form of vitamin B3) into NMN (nicotinamide mononucleotide), which is then converted into NAD+ (nicotinamide adenine dinucleotide)—a critical molecule for energy metabolism, DNA repair, and cellular survival.

By inhibiting NAMPT, these compounds reduce intracellular NAD+ levels, affecting processes that rely on NAD+-dependent enzymes such as sirtuins and PARPs. This has made NAMPT inhibitors an area of active research, particularly in:

• Cancer research: Certain tumors rely heavily on NAMPT-driven NAD+ production for survival and growth. NAMPT inhibitors are being studied for their ability to starve cancer cells of energy and promote apoptosis.
• Inflammation and autoimmune diseases: NAMPT also has roles in immune cell activation and cytokine production, so inhibitors are being investigated for anti-inflammatory potential.
• Metabolic disorders: Research explores how NAMPT inhibition influences insulin sensitivity, obesity, and metabolic homeostasis.

Examples of NAMPT inhibitors include FK866 (also known as APO866 or GMX1778) and CHS-828, both of which have been studied in preclinical and clinical trials.

Note: NAMPT inhibitors are experimental research compounds. They are not approved for medical use or supplementation, and their use is restricted to controlled scientific research.

5 Amino-1MQ — Frequently Asked Questions

1. What is 5 Amino 1MQ?

It’s a small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor—formally known as 5 amino 1-methylquinolinium. It’s been investigated in metabolic and obesity research for modulating energy balance and fat storage SwolverinePeptide Sciences.

2. How does it work?

By inhibiting NNMT, it helps preserve NAD⁺ levels, which supports mitochondrial energy production and activates sirtuin pathways like SIRT1—linked to fat oxidation, cellular repair, and metabolic efficiency

3. What are the potential benefits?

• Fat loss: In animal models, it reduced white adipose mass and cholesterol, even without changing intake

• Energy & metabolism: Proposed to improve metabolic rate, preserve lean mass, and promote energy efficiency

4. Are there anti-aging or insulin sensitivity effects?

Yes. Elevated NAD⁺ via NNMT inhibition may enhance insulin sensitivity and support age-related metabolic functions like DNA repair and inflammation control

5. What do human studies say?

Plain truth: There are no robust human trials yet. Most data come from animal and cell studies. The human efficacy and safety profile is largely unproven

6. What about side effects or risks?

Evidence is thin. Anecdotal reports suggest possible mild gastrointestinal discomfort, headaches, fatigue—but we lack rigorous human safety data

7. Is 5-Amino-1MQ approved or regulated?

Nope. It’s not FDA-approved and typically sold for “research use only.” In sports, WADA considers unapproved substances like this prohibited under category S0

8. How is it administered?

Usually oral capsules, though protocols vary. Animal studies inform doses, not human ones. No standardized dosing is established’

9. Where does research currently stand?

Promising preclinical findings—but we’re in the early stages. Without human studies, it’s speculative to draw conclusions about efficacy or safety

10. Should I use it?

Smart question: If you demand evidence, this doesn’t meet clinical standards yet. If curiosity and calculated risk are your style—and you’re outside elite sport testing—still proceed with caution and seek high-purity sources and professional oversight.