Mechanism of Action

MK-677 works by mimicking the action of ghrelin, binding to ghrelin receptors in the brain to stimulate growth hormone release. Unlike peptides, it’s orally active and provides sustained GH elevation for 24+ hours.

Benefits

• •Significant increases in muscle mass and strength
• •Improved sleep quality and REM sleep
• •Enhanced recovery between workouts
• •Increased appetite for bulking phases
• •Oral administration (no injections required)
• •24-hour growth hormone elevation

Side Effects & Negatives

• •Intense hunger and weight gain
• •Significant water retention and bloating
• •Potential rise in insulin resistance
• •Muscle pain and joint discomfort
• •Edema (fluid retention in tissues)
• •Lethargy and fatigue in some users

Safety Profile

Not FDA-approved for human use. Carries significant metabolic risks including insulin resistance and diabetes risk. The intense hunger can lead to unwanted fat gain. Long-term cardiovascular effects are unknown.

Dosage Information

Research dosing: 10-25mg daily, typically taken before bed. Higher doses increase side effects without proportional benefits. Cycling protocols vary widely.

Research Studies

• 1. Nass et al. (2008): Twelve-month MK-677 treatment in healthy older adults sustained GH and IGF-1 elevations, increased fat-free mass, and was generally well tolerated, with some reduction in glucose tolerance
• 2. Murphy et al. (1998): Eight-week study showed MK-677 reversed diet-induced nitrogen wasting and significantly increased GH and IGF-1 levels in healthy adults